Uberon and Cell Ontology recommended for Library of Integrated Network-based Cellular Signatures (LINCS)

The NIH Library of Integrated Network-based Cellular Signatures (LINCS) project aims to create a network-based understanding of biology by cataloging changes in gene expression and other cellular processes that occur when cells are exposed to a variety of perturbing agents...

The NIH Library of Integrated Network-based Cellular Signatures (LINCS) project aims to create a network-based understanding of biology by cataloging changes in gene expression and other cellular processes that occur when cells are exposed to a variety of perturbing agents, and by using computational tools to integrate this diverse information into a comprehensive view of normal and disease states that can be applied for the development of new biomarkers and therapeutics.

This project recommends the usage of Uberon and the OBO Cell Ontology for describing organs, tissues and cells for annotating reagents and assays.

See Vempati et al Metadata Standard and Data Exchange Specifications to Describe, Model, and Integrate Complex and Diverse High-Throughput Screening Data from the Library of Integrated Network-based Cellular Signatures (LINCS)

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